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Oxycodone Withdrawal: Symptoms, Timeline, and Treatment

Oxycodone Withdrawal: Symptoms, Timeline, and Treatment

Oxycodone is among the most commonly misused prescription opioids. If its misuse is left unchecked, it can be fatal. This article breaks down everything you need to know about oxycodone misuse (and withdrawal) so that you can begin to overcome it.

Oxycodone Withdrawal Symptoms

With over 10 million Americans misusing prescription opioids like oxycodone each year, understanding its withdrawal symptoms, timeline, and treatment options is vital.

Oxycodone is a powerful analgesic belonging to the opioid class of medications. Being a semi-synthetic opioid, oxycodone is commonly used for pain relief. However, it comes with the risk of dependence and withdrawal if not administered properly.

Oxycodone withdrawal can lead to effects such as anxiety and physical pain.

This guide aims to shed light on oxycodone withdrawal symptoms, offering insights and strategies for those on the path to recovery.

What is Oxycodone Withdrawal?

Oxycodone withdrawal happens when someone reliant on this potent opioid stops using it. Over time, they need higher doses for the same effect due to tolerance. Quitting leads to uncomfortable symptoms like pain, prompting some to relapse. 

Oxycodone Withdrawal Symptoms

Here are the common withdrawal symptoms for opioids like oxycodone:


During oxycodone withdrawal, anxiety often increases, causing restlessness and unease. This can make it hard to relax or focus due to worries or fear. Deep breathing or mindfulness can help ease these feelings.

Physical Pain

During withdrawal, pain is common, with muscle aches and joint pain being typical. These sensations can vary in intensity, affecting daily life. Heat packs or over-the-counter pain relievers can help temporarily, but it's crucial to consult a healthcare professional for proper pain management.


Insomnia is common due to the body adjusting to the absence of Oxycodone. Sleep problems may include trouble falling asleep, waking often at night, or restless sleep. Creating a regular bedtime routine and a comfortable sleep environment can help. 

Excessive Sweating

Excessive sweating is common as the body experiences physiological changes. This can happen more during discomfort or anxiety. Though uncomfortable, sweating usually lessens as withdrawal progresses.

If you or someone you know is experiencing any of these withdrawal symptoms, please consult your healthcare provider immediately.

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Timeline of Oxycodone Withdrawal

To manage oxycodone withdrawal, it's crucial to grasp its stages and symptoms. Here’s a table that summarizes the withdrawal timeline:

Stage Time Frame Symptoms
Early Withdrawal Within 8 hours after the last dose
  • Anxiety, restlessness, and drug cravings
  • Sweating, yawning, and runny nose
  • Insomnia and muscle aches
Peak Withdrawal Days 2-4
  • Intensified symptoms such as nausea, vomiting, and diarrhea
  • Heightened anxiety, irritability, and depression
  • Dilated pupils and abdominal cramping
Protracted Withdrawal Weeks to Months After
  • Lingering symptoms, but less severe
  • Emotional challenges, like anxiety and depression
  • Insomnia and cravings may persist but gradually improve

Treatment Approaches for Oxycodone Withdrawal

There are various treatment options to choose from, such as medical detoxification, medication-assisted treatment, and therapy and counseling.

Medical Detoxification

In medical detoxification, professionals gradually decrease your oxycodone dosage while closely monitoring your vital signs and providing medications for comfort. This approach ensures a safe environment, reducing the risk of complications and relapse for you. It's a vital initial step in stabilizing you physically, setting the stage for further treatment.

Medication-Assisted Treatment

In Medication-Assisted Treatment (MAT), you receive behavioral therapy alongside medications such as methadone, buprenorphine, or naltrexone to manage withdrawal symptoms and cravings. This approach targets both the physical and psychological aspects of oxycodone dependency, aiding in your stabilization and long-term sobriety. 

Therapy and Counseling

In therapy and counseling, you'll encounter behavioral therapies like cognitive-behavioral therapy (CBT) and motivational interviewing, which help you tackle underlying issues contributing to oxycodone dependency. Therapy offers crucial support in handling cravings, forming healthy habits, and addressing any co-occurring mental health disorders you may have.

Strategies for Coping with Oxycodone Withdrawal

Navigating oxycodone withdrawal demands a holistic approach, tackling both physical and emotional aspects of recovery. Here are strategies to guide you through this period and toward healing and sobriety:

Practice Self-Care

Make yourself a priority by engaging in self-care activities like exercise, getting enough sleep, and eating nutritious meals to support your physical and emotional well-being during withdrawal.

By nurturing both your body and mind, you'll build resilience and find the strength to cope with the challenges of oxycodone withdrawal.

Engage in Therapy

Take part in therapy sessions, like cognitive-behavioral therapy (CBT), to tackle the root causes of your addiction and discover effective coping methods. Therapy offers a safe space to explore what triggers your cravings and to build healthier ways to deal with them. Through therapy, you'll develop resilience and stay on the path to long-term recovery.

Seeking Medical Support

When you're going through withdrawal, reaching out to a healthcare professional is crucial. They'll guide you through managing symptoms safely, providing medications, and monitoring your progress for a smoother transition. Having that medical support during withdrawal can make a big difference, easing discomfort and lowering the risk of complications.

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Oxycodone Withdrawal FAQs

How long does oxycodone withdrawal last?

Withdrawal from oxycodone can vary for each person, depending on factors like how much you've been taking, how long you've been taking it, and your body's own response. Usually, the toughest symptoms peak in a few days and start to get better over about a week. However, for some people, there might be lingering symptoms that stick around for weeks or even months, 

Will hydrocodone help with oxycodone withdrawal?

If you're considering using hydrocodone to ease oxycodone withdrawal, remember that while it may help with some symptoms, it's crucial to consult a healthcare professional first. They can guide you on the safest and most effective ways to manage withdrawal. Your health and well-being are important, and getting the right support can make all the difference.

How do I stop taking oxycodone without withdrawal?

If you're looking to stop taking oxycodone without experiencing withdrawal, it's important to work closely with a healthcare provider. They'll help you gradually reduce your dosage, allowing your body to adjust slowly and minimizing withdrawal symptoms. Alongside this process, incorporating supportive therapies and lifestyle changes can help manage any discomfort you may experience.

What is the best way to get oxycodone out of your system?

Eliminating oxycodone from your system takes time. Keep yourself hydrated by drinking plenty of water to help flush out toxins more effectively. Regular physical activity and a balanced diet can also support your overall health and help your body eliminate oxycodone metabolites. Taking care of yourself in these ways can aid recovery and promote your well-being.

Start Your Journey to Recovery Today

As you navigate the symptoms, timeline, and treatment options of oxycodone withdrawal, remember that recovery is possible.

At Confidant Health, we're here for you every step of the way. Our expert team offers personalized guidance for managing withdrawal symptoms and exploring treatment options, including therapy sessions and medication-assisted treatment. With our virtual services, you can receive care from the comfort of your home.

We understand the challenges you're facing, and we're here to help you overcome them. Reach out to Confidant Health today, and let’s work together towards recovery. 

This article has been medically reviewed by
Erin Hillers
Erin Hillers
Erin Hillers
Nurse Practitioner

Erin is a Nurse Practitioner with 8 years of experience in midwifery and women's health. She has spent the past 5 years specializing in the treatment of opioid and alcohol use disorders.

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